New studies, clinical guidance and reported developments in gut health and IBD research, and what each one means for people living with a digestive condition.
New research has identified a significant association between inflammatory bowel disease (IBD) and reduced activation of the bile acid receptor TGR5, alongside altered bile acid profiles that correlate with inflammatory activity. The findings, reported by EMJ Gastroenterology, suggest a potential mechanistic link between bile acid signalling and intestinal inflammation in Crohn’s disease and ulcerative colitis. […]
A systematic review of randomised controlled trials has examined whether previous biologic therapy affects the efficacy of upadacitinib in inflammatory bowel disease (IBD), addressing a key question for clinicians positioning newer oral agents within treatment pathways. The analysis, published in Cureus, sought to clarify how prior exposure to biologic therapies influences outcomes with the Janus […]
Active inflammation, rather than the presence of a fistula in itself, is the main driver of reduced health-related quality of life (HRQoL) in Crohn’s disease (CD), according to a study of 209 patients published in Digestive Diseases and Sciences. The research examined how disease phenotype, treatment approach and clinical disease activity each relate to patient […]
Researchers at McMaster University in Canada have used bacteriophages to disarm a bacterium associated with Crohn’s disease, reducing gut inflammation and improving the response to corticosteroids in preclinical models. The study, published in Science Translational Medicine, targets adherent-invasive Escherichia coli (AIEC) strains isolated from patients with Crohn’s disease. This is laboratory and animal research; phage […]
Researchers have identified a genetic marker strongly associated with severe inflammatory bowel disease (IBD), potentially enabling earlier intervention with advanced therapies. The HLA-DRB1*01:03 variant, present in approximately one in 20 patients, predicts greater need for surgery and biological treatment in both Crohn’s disease and ulcerative colitis. Background IBD encompasses Crohn’s disease and ulcerative colitis, chronic […]
Three recently reported developments in inflammatory bowel disease (IBD) research underscore a growing shift towards mechanism-based, personalised treatment. The findings address long-standing questions about why Crohn’s disease and ulcerative colitis affect individuals differently and why many patients continue to experience disease instability despite advanced therapies. Background Context IBD encompasses a spectrum of chronic inflammatory conditions […]
Researchers have identified a previously unrecognised network of cells in the intestine that could offer new insights into tissue healing and inflammatory bowel disease. The discovery, announced by EurekAlert!, may help explain why some patients experience impaired gut repair and could inform future therapeutic strategies for Crohn’s disease and ulcerative colitis. Background Context The intestinal […]
Guts UK, the national charity for the digestive system, has launched a week-long campaign encouraging people to talk more openly about their gut health. The Let’s Talk Guts campaign, running from 13 to 19 July, aims to reduce embarrassment and help people feel more confident discussing digestive symptoms with family, friends, employers, and healthcare professionals. […]
A new medicine called duvakitug has shown encouraging results in an early clinical trial for people with Crohn’s disease, according to findings published in The Lancet Gastroenterology & Hepatology. The study, known as RELIEVE UCCD, tested whether the drug could help control inflammation and symptoms in people living with the condition. Whilst the results are […]
Doctors in the United States have reported the first use of a new ultrasound imaging system to examine growths in the rectum during outpatient procedures. The technology, which combines imaging with treatment capabilities, was used successfully in two patients at an ambulatory surgical centre. What the team reported The medical team from HCA Healthcare published […]
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