Health News

Clinicians are increasingly turning to intestinal ultrasound (IUS) as a way to monitor inflammatory bowel disease (IBD) without the bowel preparation, sedation, or recovery time required for colonoscopy. A recent report highlights how this point-of-care imaging technique is being adopted more widely in gastroenterology clinics to track disease activity in Crohn’s disease and ulcerative colitis. […]

I’m not able to produce this article. The source material is a personal account from a named individual (Amy Dowden) describing her own experience with Crohn’s disease, including her feelings, fears, and career history. This falls squarely within the Golden Rule stating: “Do not generate any article that refers to a human story, testimonial or […]

The US Food and Drug Administration (FDA) has approved a new way of starting treatment with risankizumab, a biologic medicine already used for Crohn’s disease, allowing the initial doses to be given as an injection under the skin rather than through a drip into a vein. AbbVie, the company that makes the medicine under the […]

A new medicine being developed for inflammatory bowel disease (IBD) has shown encouraging results in a mid-stage clinical trial, with many participants experiencing long-term symptom control. The drug, called duvakitug, is being developed jointly by Sanofi and Teva Pharmaceuticals for people with ulcerative colitis (UC) and Crohn’s disease, two long-term conditions that cause inflammation in […]

Teva Pharmaceuticals and Sanofi have announced new results from an ongoing trial of an experimental medicine called duvakitug, used in people with moderate to severe ulcerative colitis or Crohn’s disease. The companies reported that improvements seen earlier in the study were still present after 44 weeks of treatment. The findings may be relevant to people […]

AbbVie has presented early-stage data suggesting that ABBV-466, an investigational dual-targeting therapy, achieved higher rates of endoscopic remission in people with moderate to severe Crohn’s disease than either of the single-pathway treatments it was compared against. The findings, disclosed by AbbVie, point to a potential new option for patients whose disease does not respond adequately […]

Eli Lilly has reported findings from two late-stage clinical trials, LUCENT-2 and VIVID-1, suggesting that its interleukin-23 (IL-23) inhibitor mirikizumab, marketed as Omvoh, offers benefits across multiple aspects of disease control in both ulcerative colitis (UC) and Crohn’s disease (CD). The results point to a treatment approach that extends beyond standard remission measures to address […]

Most people rarely think about what is normal for their own bowel movements until something changes. Doctors say certain shifts in colour, texture or frequency can be an early sign that something needs medical attention, while others are harmless and linked to diet or medicines. Understanding the difference may help people with digestive symptoms know […]

New research is drawing attention to the practical, everyday challenges faced by people with Crohn’s disease, a long-term condition that falls under the wider category of inflammatory bowel disease (IBD). A global review of how common IBD is around the world, alongside separate research into workplace experiences of people with conditions that are not visible […]

A study presented at a major US gastroenterology conference has found that women with inflammatory bowel disease (IBD) who use fertility treatment can reach high pregnancy rates overall, but success varied considerably depending on the type of treatment used. The researchers suggested that embryo transfer may offer notably better results than a simpler insemination procedure, […]

Irritable bowel syndrome (IBS) affects an estimated 15 per cent of people worldwide, yet its symptoms vary so widely between individuals that diagnosis and treatment can be challenging. New patient guidance sets out a clear pathway for people experiencing ongoing digestive symptoms, emphasising the importance of medical assessment before any dietary changes are made, and […]

A clinical pharmacist has outlined several everyday habits that may help people manage chronic, long-term inflammation in the body, according to a recent interview reported by Fox News Digital. The comments matter for anyone living with inflammatory bowel disease (IBD) or other conditions linked to inflammation, since lifestyle factors are often raised alongside, but not […]

New figures suggest a sharp rise in people over 50 being diagnosed with ADHD or autism, with many only recognising these conditions later in life. The data, from a UK travel insurance provider, shows a marked increase in customers declaring these conditions when buying cover. The findings matter because they point to growing awareness of […]

Johnson & Johnson has reported two-year results for icotrokinra, an oral medicine for moderate to severe plaque psoriasis, a long-term skin condition that causes raised, scaly patches. The findings, presented at a dermatology conference, showed that many people kept clear or almost clear skin over two years of treatment. Because the medicine blocks a target […]

A new study has found that people with inflammatory bowel disease (IBD) tend to have lower vitamin D levels than those without the condition, and that levels drop further during flare-ups. Vance Health Hub reports on findings suggesting that blood vitamin D tests could, in future, help doctors track how active a person’s IBD is […]

A final-year medical student is scootering the length of New Zealand to raise funds for Crohn’s & Colitis New Zealand (CCNZ) and to draw attention to an everyday concern for people with inflammatory bowel disease (IBD): finding a clean, accessible toilet. His journey highlights a practical issue that affects thousands of people living with Crohn’s […]

A new multi-omics analysis of 178 people with inflammatory bowel disease (IBD) has identified two distinct gut microbiome enterotypes, patient groupings defined by characteristic combinations of gut bacteria, with markedly different metabolic signatures. The findings suggest that IBD, which includes Crohn’s disease and ulcerative colitis, may encompass biologically distinct subtypes rather than a single uniform […]

Researchers at the University of California, Los Angeles (UCLA) Health and Mount Sinai have received four million US dollars in federal funding to examine why some people with ulcerative colitis continue to experience bowel symptoms even after inflammation has eased. The five-year study could help explain a pattern that affects a significant number of people […]

Eli Lilly has announced it will present new research findings on several of its skin condition treatments at a dermatology conference this October, including studies on a psoriasis medicine called…

An experimental medicine for a difficult-to-treat form of Crohn’s disease has shown promising results in an extended study, according to its developer, Agomab Therapeutics. The company reported that most participants taking the drug, called ontunisertib, remained in remission after nearly a year of treatment. The findings could be relevant for people living with Crohn’s disease […]

Children with Crohn’s disease who switch from one biologic medicine to another may need different blood level targets than those starting treatment for the first time, according to a new study. Researchers found that children who moved from adalimumab to infliximab had lower infliximab levels in their blood, yet still reached similar remission rates. The […]

A new engineering review has outlined nanomaterial based drug delivery platforms designed to exploit differences in enzyme activity between the healthy gut microbiome and inflamed colonic tissue in inflammatory bowel disease (IBD). Published in the International Journal of Nanomedicine, the work describes how these engineered carriers could allow treatments to be released more precisely at […]

A new study has found that people living with inflammatory bowel disease (IBD) are not at increased risk of high blood pressure problems during pregnancy overall, although certain specific risks, including preeclampsia, were higher. The findings may reassure many people with IBD who are pregnant or planning a pregnancy, while highlighting the value of closer […]

Lead Paragraph New follow-up data reported by DocWire News indicate that clinical benefits associated with early “top-down” treatment for moderate to severe Crohn’s disease persisted over five years. The findings add to the evidence base supporting earlier use of advanced therapies rather than waiting for conventional treatments to fail, a distinction relevant to gastroenterologists managing […]

Palisade Bio has announced that the US Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for PALI-2108 in Crohn’s disease. The clearance allows the compound to progress into clinical testing for this indication, building on the company’s existing development programme in ulcerative colitis (UC) and marking an expansion of its […]

New research presented at a Brazilian medical conference suggests that inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has become far more common in Brazil over the past decade. The findings matter because they point to a wider global pattern, with more people, including younger adults, potentially living with these lifelong digestive […]

A new study reported in Nature Medicine has identified strains of the fungus Candida moving from the mouth into the gut in people with inflammatory bowel disease (IBD), according to research discussed by Iliyan D. Iliev, PhD, of Weill Cornell Medicine. The findings add to growing evidence that the oral and intestinal microbiomes are more […]

A large retrospective study presented at the 2026 Annual Scientific Meeting of the American Society of Colon and Rectal Surgeons has found that surgical intervention for inflammatory bowel disease (IBD) has become markedly less common over the past two decades, coinciding with the wider use of biologic therapies. The findings suggest that modern medical treatment […]

A new analysis reported by Medscape suggests that elevated levels of a serum protein called regenerating islet-derived 3-alpha (REG3-alpha) are linked to a greater likelihood of disease progression in people who go on to develop Crohn’s disease (CD), with raised levels detectable years before diagnosis. The finding points to a potential early warning marker for […]

Lead Several new lines of inflammatory bowel disease (IBD) research reported this week point to a shift away from broad immune suppression and towards more precise, structurally focused care. Findings span a previously unrecognised cellular vulnerability linked to relapse, a naturally derived compound that may support gut barrier repair, and a call from clinicians to […]

Lead The National Institute for Health and Care Excellence (NICE) has approved guselkumab as a new biologic treatment option for adults with moderate to severe ulcerative colitis and active Crohn’s disease. The decision extends treatment choices for patients who have not responded adequately to existing therapies, offering clinicians another option when conventional and biological drugs […]

Researchers have found that a form of bowel inflammation linked to a rare liver condition behaves differently from a more common type of inflammatory bowel disease (IBD), even though the two look similar and are currently treated the same way. The findings may help explain why people with the rarer condition face a higher risk […]

Lead Paragraph A large international study has found that eating high amounts of ultra-processed grains is associated with a substantially increased risk of developing inflammatory bowel disease (IBD), while diets built around fresh staples such as rice and bread appear protective. The research, involving more than 124,000 participants across 21 countries, adds to growing evidence […]

Adults newly diagnosed with Crohn’s disease who received a combination of two medicines straight after diagnosis needed far fewer operations and hospital admissions over the following five years than those given standard step-by-step treatment, according to long-term results from a UK trial. The findings, reported in The Lancet, could influence how doctors approach treatment as […]

Lead Paragraph Researchers at the UNC School of Medicine have identified a mechanism that may explain why some plant foods aggravate symptoms in certain people with inflammatory bowel disease (IBD). Their study, published in Cellular and Molecular Gastroenterology and Hepatology, found that patients with Crohn’s disease and ulcerative colitis often have reduced levels of transporter […]

I’m unable to produce this article. The “source material” provided is not an actual article, study, or press release, it is a browser/website error message (“A required part of this site couldn’t load… please check your connection, disable any ad blockers, or try using a different browser”). There is no scientific content, findings, methodology, or […]

Lead Paragraph Researchers have highlighted a potential role for gut bacteria in explaining why some patients with inflammatory bowel disease (IBD) experience worsened gut inflammation after eating oxalate-rich vegetables such as spinach, according to a report by SciTechDaily. The findings point to oxalate-degrading bacteria within the gut microbiome as a possible alternative to strict dietary […]

New UK-wide standards for inflammatory bowel disease (IBD) care, alongside a cluster of research published this month, signal a shift toward more individualised management of Crohn’s disease and ulcerative colitis. The developments, spanning national service benchmarks, treatment de-escalation guidance, dietary therapy and molecular diagnostics, point to care increasingly guided by a patient’s underlying biology rather […]

Researchers hope that a powerful new microscope could help identify the underlying biological drivers of inflammatory bowel disease (IBD), according to reporting by The Guardian. The technology is intended to let scientists examine gut tissue in far greater detail than has previously been possible, with the aim of understanding why Crohn’s disease and ulcerative colitis […]

Researchers at Cambridge University Hospitals have found that starting Crohn’s disease patients on more potent treatments soon after diagnosis, rather than waiting until symptoms escalate, could reduce the risk of long-term complications. The findings, from the Addenbrooke’s Hospital IBD Clinical Research Group, challenge the conventional step-up approach to managing the condition. Crohn’s disease is a […]

A narrative review published in the Cureus Journal of Medical Science has examined how researchers assess probiotic effects on the gut microbiome, highlighting that faecal sampling, the most common method used in microbiome studies, may not fully capture what is happening at the gut lining. The review notes that mucosal microbiota samples have proven more […]

Researchers have identified two separate genetic findings that could reshape how clinicians predict and treat inflammatory bowel disease (IBD). One study links a specific genetic marker to more severe Crohn’s disease and ulcerative colitis, while another uncovers a cellular pathway that drives gut inflammation. Together, they point towards a future where treatment decisions are guided […]

A paediatric gastroenterologist has called for a wider range of treatments for children with Crohn’s disease, a long-term condition that causes inflammation in the digestive system. Speaking to Korea Biomedical Review, Professor Kim Mi-jin of Samsung Medical Center said children currently have far fewer medicine options than adults, making it harder for doctors to adjust […]

Despite a decade of biologic and targeted therapy development, many people with inflammatory bowel disease (IBD) still cycle through flares, treatment escalation and loss of response, according to discussions at Digestive Disease Week (DDW) 2026. Experts speaking at the meeting argued that achieving durable, deep remission, rather than simply controlling acute symptoms, should become the […]

Researchers have used artificial intelligence and network medicine techniques to map how inflammatory bowel disease (IBD) connects to other health conditions, including mental health and musculoskeletal disorders. Drawing on large electronic health registries covering thousands of patients, the analysis identifies stable patterns of associated conditions that could help clinicians anticipate complications earlier and move towards […]

A new study reported by ScienceDaily suggests that oxalate, a naturally occurring compound found in many otherwise healthy foods, may aggravate intestinal inflammation in people with inflammatory bowel disease (IBD). Researchers point to a potential role for gut bacteria in breaking down oxalate before it can trigger this effect, opening a possible new avenue for […]

Patients at Bronglais Hospital in Aberystwyth have become the first in the UK to join two international studies testing possible new treatments for Crohn’s disease and ulcerative colitis. Both conditions are long-term forms of inflammatory bowel disease (IBD) that affect the digestive system. The milestone means people in west Wales can take part in early-stage […]

New research highlighted by Vance Health Hub suggests that higher consumption of ultra-processed foods may be associated with an increased risk of relapse in people living with Crohn’s disease. The findings, reported by the European Medical Journal (EMJ), point to potential disruption of the gut microbiome and increased intestinal permeability as possible explanations, adding to […]

Researchers at McMaster University and the Massachusetts Institute of Technology have used artificial intelligence to identify a new antibiotic, named enterololin, that targets harmful gut bacteria while leaving beneficial microbes untouched. The finding, published in Nature Microbiology, could offer a more precise alternative to broad-spectrum antibiotics for people with gastrointestinal conditions, including those living with […]

People with inflammatory bowel disease (IBD) already have a higher chance of developing bowel cancer than the general population. A large study from Sweden suggests that looking closely at how many close relatives have had bowel cancer, not just whether one relative was diagnosed young, could help doctors identify which patients face the greatest risk. […]

A new review of research into inflammatory bowel disease (IBD) treatments has found that certain medicines, particularly a type called thiopurines and a class known as anti-tumour necrosis factor (anti-TNF) medicines, are linked to a higher risk of some cancers. The findings may help patients and their doctors think through the benefits and risks of […]

Researchers report that treating candida overgrowth with antifungal therapy may help shift the gut microbiome of some inflammatory bowel disease (IBD) patients towards a healthier composition. The findings suggest that fungal populations in the gut, not just bacteria, could play a role in the disease process, though the researchers describe the results as an early […]

A new cross-sectional study has examined nutritional status in people with Crohn’s disease (CD) using several assessment approaches together, rather than relying on a single measure. Published in PLOS ONE, the research underscores malnutrition as a common but frequently overlooked complication of CD, one that may affect patients’ daily functioning, their tolerance of treatment, and […]

People with inflammatory bowel disease (IBD) who have several close family members diagnosed with bowel cancer appear to face a notably higher risk of developing the disease themselves, according to a large Swedish study. The findings suggest that current screening guidance, which focuses mainly on whether one relative was diagnosed young, may not fully capture […]

Lead The US Food and Drug Administration (FDA) has approved ustekinumab, sold as Stelara, for treating moderately to severely active ulcerative colitis (UC) in paediatric patients, according to reporting from the pharmacy publication Drug Topics. The decision extends an existing adult UC indication and a paediatric Crohn’s disease indication to a younger group of patients […]

A large study of more than 100,000 children has found that a healthier lifestyle in the earliest years of life may be linked to a lower chance of developing inflammatory bowel disease (IBD) later on. The link was strongest for Crohn’s disease. The findings suggest that everyday factors in infancy could play a part in […]

Lead Paragraph A large prospective study has found that people with higher intake of ultra-processed food face an increased risk of developing inflammatory bowel disease (IBD), a group of chronic conditions that includes Crohn’s disease and ulcerative colitis. Published in The BMJ, the findings add substantial weight to long-standing questions about whether modern dietary patterns […]

Lead Paragraph Researchers have identified early molecular changes in the gut lining that appear to precede the onset of noticeable symptoms in people with inflammatory bowel disease (IBD), according to newly reported findings. The work suggests that gut cells can become primed for inflammatory damage well before a clinical diagnosis is made, a finding relevant […]

A hospital in Hyderabad has opened a new laboratory dedicated to studying the trillions of microbes living in the human gut, with an early focus on inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease. The facility aims to explore whether gut bacteria could one day support new research approaches for people living […]

An international panel of gastroenterology experts has published consensus guidance on identifying and managing irritable bowel syndrome (IBS) like symptoms in patients with inflammatory bowel disease (IBD) who are otherwise in remission. The statement, reported by the HMP Global Learning Network, responds to a persistent clinical challenge affecting a substantial minority of patients whose bowel […]

Lead Paragraph Researchers at the University of North Carolina (UNC) School of Medicine have investigated whether oxalate, a naturally occurring compound found in foods such as spinach and almonds, may contribute to worsening gut inflammation in people living with inflammatory bowel disease (IBD). The findings, reported by Medical Xpress, add to ongoing efforts to understand […]

A cluster of newly reported studies is pointing toward a more individualised model of care for people with inflammatory bowel disease (IBD). Findings spanning early-life microbiome changes, bacterial metabolites, combination biologic therapy, genetic risk markers and diet suggest that both Crohn’s disease and ulcerative colitis are increasingly understood as conditions shaped by a combination of […]

A new study suggests that some people with long-term bowel conditions may also be at risk of a lung problem involving scarring and inflammation. The link appeared stronger in people with ulcerative colitis than in those with Crohn’s disease. Researchers say the findings may help doctors pay closer attention to breathing symptoms in people living […]

Lead Paragraph A cluster of new research is reshaping how clinicians think about treating inflammatory bowel disease (IBD). Developments spanning patient-derived gut organoid models, pH-sensitive drug delivery systems, genetic and antibody profiling, and a new monoclonal antibody in clinical trials point towards more individualised approaches to managing Crohn’s disease and ulcerative colitis, moving care away […]

A large study has found that people exposed to higher levels of outdoor artificial light at night may have a lower chance of developing inflammatory bowel disease (IBD), a long-term condition that causes inflammation in the digestive system. The findings, drawn from population data, also suggest that people with IBD who lived in brighter night-time […]

A new genetic marker, HLA-DRB1*01:03, has been linked to more severe forms of Crohn’s disease and ulcerative colitis, according to researchers at the Wellcome Sanger Institute. The marker was identified in around one in twenty people with inflammatory bowel disease (IBD) after analysis of samples from more than 43,000 patients, raising the prospect of earlier, […]

An investigational monoclonal antibody targeting TNF-like ligand 1A (TL1A), known as duvakitug, has shown a “robust” clinical response in patients with Crohn’s disease and ulcerative colitis, according to trial data reported by Healio and summarised in Nature Reviews Gastroenterology & Hepatology. The findings are relevant to UK clinicians managing patients with inflammatory bowel disease (IBD) […]

Lead Paragraph Researchers at Monash University have developed miniature, lab-grown intestinal models, known as organoids, using live tissue and bacteria taken from the gut. The models aim to improve understanding of paediatric inflammatory bowel disease (IBD) and could help scientists study how the condition develops in children, a group in which research options have historically […]

A new research review has identified adipose tissue and skeletal muscle composition as potential predictors of biologic treatment response in patients with Crohn’s disease. The findings suggest body composition analysis could help clinicians anticipate which patients may experience treatment failure on biologic therapy. Background Context Biologic therapies have transformed management of moderate to severe Crohn’s […]

Researchers have identified distinct metabolic signatures in stool samples that may help predict which patients with Crohn’s disease are at higher risk of developing complications. The findings, published in a recent metabolomic profiling study, suggest that non-invasive faecal testing could one day support earlier clinical decision making in inflammatory bowel disease (IBD) management. Background Context […]

Two recent studies have identified genetic and cellular markers that may allow clinicians to predict severe inflammatory bowel disease (IBD) earlier and understand why inflammation persists even after visible healing. The findings, drawn from data covering more than 43,000 patients and detailed cellular mapping of gut tissue, suggest that personalised treatment strategies could soon move […]

A new Swedish population study has found that people with inflammatory bowel disease (IBD) face a significantly elevated risk of depression, anxiety, and substance misuse in the years preceding their diagnosis. The findings, reported by CTV News, reinforce observations made by Canadian and international IBD specialists and highlight the importance of recognising psychiatric comorbidity in […]

The University of Miami Miller School of Medicine has announced a new research initiative investigating whether personalised anti-inflammatory dietary interventions can reduce inflammation in people living with Crohn’s disease. The study forms part of the institution’s broader precision medicine approach to inflammatory bowel disease (IBD), which includes identifying genetic variants associated with medication-related adverse effects. […]

Researchers have discovered that approximately 3.5% of people with inflammatory bowel disease (IBD) produce autoantibodies that block interleukin-10, a protein that normally dampens inflammation. The finding, drawn from data involving more than 4,900 patients, links a known genetic risk factor to severe, uncontrolled bowel inflammation and supports the view that IBD encompasses multiple biologically distinct […]

Patients with inflammatory bowel disease face a substantially elevated risk of developing psychiatric disorders, beginning two to three years before IBD diagnosis and persisting for up to a decade afterwards, according to new research reported by News-Medical.Net and Neuroscience News. The findings highlight a significant bidirectional relationship between gastrointestinal and mental health in this patient […]

Guts UK has published advice to help people with digestive conditions make the most of summer without overexerting themselves. The charity suggests a range of activities that can be adapted to individual energy levels and symptom management needs, recognising that warmer weather and changes in routine can affect how the gut behaves. Managing summer with […]

New research has identified a connection between inflammatory bowel disease and reduced activation of TGR5, a bile acid receptor that plays a key role in metabolic and immune regulation. The findings, published in EMJ, suggest that altered bile acid profiles in IBD patients may contribute to ongoing inflammatory activity in the gut. Background Context TGR5, […]

New research has identified a significant association between inflammatory bowel disease (IBD) and reduced activation of the bile acid receptor TGR5, alongside altered bile acid profiles that correlate with inflammatory activity. The findings, reported by EMJ Gastroenterology, suggest a potential mechanistic link between bile acid signalling and intestinal inflammation in Crohn’s disease and ulcerative colitis. […]

A systematic review of randomised controlled trials has examined whether previous biologic therapy affects the efficacy of upadacitinib in inflammatory bowel disease (IBD), addressing a key question for clinicians positioning newer oral agents within treatment pathways. The analysis, published in Cureus, sought to clarify how prior exposure to biologic therapies influences outcomes with the Janus […]

Active inflammation, rather than the presence of a fistula in itself, is the main driver of reduced health-related quality of life (HRQoL) in Crohn’s disease (CD), according to a study of 209 patients published in Digestive Diseases and Sciences. The research examined how disease phenotype, treatment approach and clinical disease activity each relate to patient […]

Researchers at McMaster University in Canada have used bacteriophages to disarm a bacterium associated with Crohn’s disease, reducing gut inflammation and improving the response to corticosteroids in preclinical models. The study, published in Science Translational Medicine, targets adherent-invasive Escherichia coli (AIEC) strains isolated from patients with Crohn’s disease. This is laboratory and animal research; phage […]

Researchers have identified a genetic marker strongly associated with severe inflammatory bowel disease (IBD), potentially enabling earlier intervention with advanced therapies. The HLA-DRB1*01:03 variant, present in approximately one in 20 patients, predicts greater need for surgery and biological treatment in both Crohn’s disease and ulcerative colitis. Background IBD encompasses Crohn’s disease and ulcerative colitis, chronic […]