New studies, clinical guidance and reported developments in gut health and IBD research, and what each one means for people living with a digestive condition.
Lead Paragraph Researchers have identified early molecular changes in the gut lining that appear to precede the onset of noticeable symptoms in people with inflammatory bowel disease (IBD), according to newly reported findings. The work suggests that gut cells can become primed for inflammatory damage well before a clinical diagnosis is made, a finding relevant […]
A hospital in Hyderabad has opened a new laboratory dedicated to studying the trillions of microbes living in the human gut, with an early focus on inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease. The facility aims to explore whether gut bacteria could one day support new research approaches for people living […]
An international panel of gastroenterology experts has published consensus guidance on identifying and managing irritable bowel syndrome (IBS) like symptoms in patients with inflammatory bowel disease (IBD) who are otherwise in remission. The statement, reported by the HMP Global Learning Network, responds to a persistent clinical challenge affecting a substantial minority of patients whose bowel […]
Lead Paragraph Researchers at the University of North Carolina (UNC) School of Medicine have investigated whether oxalate, a naturally occurring compound found in foods such as spinach and almonds, may contribute to worsening gut inflammation in people living with inflammatory bowel disease (IBD). The findings, reported by Medical Xpress, add to ongoing efforts to understand […]
A cluster of newly reported studies is pointing toward a more individualised model of care for people with inflammatory bowel disease (IBD). Findings spanning early-life microbiome changes, bacterial metabolites, combination biologic therapy, genetic risk markers and diet suggest that both Crohn’s disease and ulcerative colitis are increasingly understood as conditions shaped by a combination of […]
A new study suggests that some people with long-term bowel conditions may also be at risk of a lung problem involving scarring and inflammation. The link appeared stronger in people with ulcerative colitis than in those with Crohn’s disease. Researchers say the findings may help doctors pay closer attention to breathing symptoms in people living […]
Lead Paragraph A cluster of new research is reshaping how clinicians think about treating inflammatory bowel disease (IBD). Developments spanning patient-derived gut organoid models, pH-sensitive drug delivery systems, genetic and antibody profiling, and a new monoclonal antibody in clinical trials point towards more individualised approaches to managing Crohn’s disease and ulcerative colitis, moving care away […]
A large study has found that people exposed to higher levels of outdoor artificial light at night may have a lower chance of developing inflammatory bowel disease (IBD), a long-term condition that causes inflammation in the digestive system. The findings, drawn from population data, also suggest that people with IBD who lived in brighter night-time […]
A new genetic marker, HLA-DRB1*01:03, has been linked to more severe forms of Crohn’s disease and ulcerative colitis, according to researchers at the Wellcome Sanger Institute. The marker was identified in around one in twenty people with inflammatory bowel disease (IBD) after analysis of samples from more than 43,000 patients, raising the prospect of earlier, […]
An investigational monoclonal antibody targeting TNF-like ligand 1A (TL1A), known as duvakitug, has shown a “robust” clinical response in patients with Crohn’s disease and ulcerative colitis, according to trial data reported by Healio and summarised in Nature Reviews Gastroenterology & Hepatology. The findings are relevant to UK clinicians managing patients with inflammatory bowel disease (IBD) […]
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