Researchers have identified the mechanism by which a specific genetic variant, HLA-DRB1*01:03, drives more aggressive inflammatory bowel disease (IBD) by triggering autoantibodies that neutralise interleukin-10, a key anti-inflammatory protein. The discovery, published after three decades of investigation, may enable earlier identification of high-risk patients and inform targeted treatment strategies for both Crohn’s disease and ulcerative […]
Three recently reported developments in inflammatory bowel disease (IBD) research underscore a growing shift towards mechanism-based, personalised treatment. The findings address long-standing questions about why Crohn’s disease and ulcerative colitis affect individuals differently and why many patients continue to experience disease instability despite advanced therapies. Background Context IBD encompasses a spectrum of chronic inflammatory conditions […]
Researchers have identified a previously unrecognised network of cells in the intestine that could offer new insights into tissue healing and inflammatory bowel disease. The discovery, announced by EurekAlert!, may help explain why some patients experience impaired gut repair and could inform future therapeutic strategies for Crohn’s disease and ulcerative colitis. Background Context The intestinal […]
Guts UK, the national charity for the digestive system, has launched a week-long campaign encouraging people to talk more openly about their gut health. The Let’s Talk Guts campaign, running from 13 to 19 July, aims to reduce embarrassment and help people feel more confident discussing digestive symptoms with family, friends, employers, and healthcare professionals. […]
Researchers from the University of Oxford, Newcastle University, and the University of Cambridge have identified autoantibodies against interleukin-10 (IL-10) in approximately 3.5% of inflammatory bowel disease (IBD) patients, offering a biological explanation for a genetic marker previously linked to severe disease and pointing toward more targeted treatment strategies. Background Context Interleukin-10 is a key regulatory […]
Duvakitug, an investigational monoclonal antibody targeting interleukin-23, has demonstrated efficacy as an induction therapy for patients with inflammatory bowel disease (IBD), according to new research reported in MedPage Today. The findings add to the evolving landscape of advanced biologics for Crohn’s disease and ulcerative colitis. Background Context Interleukin-23 (IL-23) is a pro-inflammatory cytokine that plays […]
A new medicine called duvakitug has shown encouraging results in an early clinical trial for people with Crohn’s disease, according to findings published in The Lancet Gastroenterology & Hepatology. The study, known as RELIEVE UCCD, tested whether the drug could help control inflammation and symptoms in people living with the condition. Whilst the results are […]
Researchers have identified a specific immune mechanism that explains why some people develop severe inflammatory bowel disease (IBD). The discovery links a genetic variant to an autoimmune response that blocks a key anti-inflammatory protein, offering hope for more targeted treatments. For patients who have struggled with trial and error approaches to treatment, this finding marks […]
Doctors in the United States have reported the first use of a new ultrasound imaging system to examine growths in the rectum during outpatient procedures. The technology, which combines imaging with treatment capabilities, was used successfully in two patients at an ambulatory surgical centre. What the team reported The medical team from HCA Healthcare published […]
A medicine already used to treat inflammatory bowel disease (IBD) may help people with a difficult form of Crohn’s disease affecting the area around the anus, according to research published…
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