For many people living with Crohn’s disease or ulcerative colitis, the two main forms of inflammatory bowel disease (IBD), colonoscopy is already a familiar part of diagnosis and monitoring flares. But after several years of disease, a gastroenterologist may recommend a different kind of colonoscopy, one done not because of symptoms, but as a planned, […]
Lead Paragraph A cluster of new research is reshaping how clinicians think about treating inflammatory bowel disease (IBD). Developments spanning patient-derived gut organoid models, pH-sensitive drug delivery systems, genetic and antibody profiling, and a new monoclonal antibody in clinical trials point towards more individualised approaches to managing Crohn’s disease and ulcerative colitis, moving care away […]
A large study has found that people exposed to higher levels of outdoor artificial light at night may have a lower chance of developing inflammatory bowel disease (IBD), a long-term condition that causes inflammation in the digestive system. The findings, drawn from population data, also suggest that people with IBD who lived in brighter night-time […]
Persistent tiredness is one of the most common complaints among people living with Crohn’s disease or ulcerative colitis, often dismissed as an inevitable part of having inflammatory bowel disease (IBD). Frequently, though, this fatigue has a specific, treatable cause: iron deficiency, with or without anaemia (a condition where the blood has too few healthy red […]
A new genetic marker, HLA-DRB1*01:03, has been linked to more severe forms of Crohn’s disease and ulcerative colitis, according to researchers at the Wellcome Sanger Institute. The marker was identified in around one in twenty people with inflammatory bowel disease (IBD) after analysis of samples from more than 43,000 patients, raising the prospect of earlier, […]
An investigational monoclonal antibody targeting TNF-like ligand 1A (TL1A), known as duvakitug, has shown a “robust” clinical response in patients with Crohn’s disease and ulcerative colitis, according to trial data reported by Healio and summarised in Nature Reviews Gastroenterology & Hepatology. The findings are relevant to UK clinicians managing patients with inflammatory bowel disease (IBD) […]
Many people living with inflammatory bowel disease (IBD) focus their attention on digestive symptoms and flares, and understandably so. But bone health is often a quieter concern that develops gradually in the background, sometimes without any obvious symptoms until a fracture or a routine scan brings it to light. What is bone health in the […]
Lead Paragraph Researchers at Monash University have developed miniature, lab-grown intestinal models, known as organoids, using live tissue and bacteria taken from the gut. The models aim to improve understanding of paediatric inflammatory bowel disease (IBD) and could help scientists study how the condition develops in children, a group in which research options have historically […]
If you have been diagnosed with ulcerative colitis (UC), there is a strong chance your gastroenterologist has prescribed a 5-ASA medication. These drugs form the backbone of treatment for mild to moderate disease, and many people with UC take them for years to control inflammation and maintain remission. What are 5-ASAs? 5-ASA stands for 5-aminosalicylic […]
If you’ve been diagnosed with Crohn’s disease or ulcerative colitis, your doctor may have mentioned azathioprine, mercaptopurine, or methotrexate. These immunomodulators work by calming an overactive immune system. Understanding how they work and what to expect can help you feel more confident about your treatment. What are immunomodulators? Immunomodulators are medications that adjust immune system […]
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